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1

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

Schwartz, Daniella M., Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 625 KB

english, 2017

2

Selective Janus kinase inhibitors come of age

O’Shea, John J., Gadina, Massimo

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2019

Language:

english

File:

PDF, 411 KB

english, 2019

3

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention*

O'Shea, John J., Schwartz, Daniella M., Villarino, Alejandro V., Gadina, Massimo, McInnes, Iain B., Laurence, Arian

Journal:

Annual Review of Medicine

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

4

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

Banerjee, Shubhasree, Biehl, Ann, Gadina, Massimo, Hasni, Sarfaraz, Schwartz, Daniella M.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.55 MB

english, 2017

5

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.

Journal:

Journal of Leukocyte Biology

Year:

2018

Language:

english

File:

PDF, 370 KB

english, 2018

6

Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation

Zhou, Y.-J., Magnuson, K. S., Cheng, T. P., Gadina, M., Frucht, D. M., Galon, J., Candotti, F., Geahlen, R. L., Changelian, P. S., O'Shea, J. J.

Journal:

Molecular and Cellular Biology

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

7

Targeting cytokine signaling in autoimmunity: back to the future and beyond

Hirahara, Kiyoshi, Schwartz, Daniella, Gadina, Massimo, Kanno, Yuka, O'Shea, John J

Journal:

Current Opinion in Immunology

Year:

2016

Language:

english

File:

PDF, 910 KB

english, 2016

8

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

Schwartz, Daniella M., Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J.

Journal:

Nature Reviews Drug Discovery

Year:

2017

File:

PDF, 54 KB

2017

9

Cytokine regulation of IL-12 receptor β2 expression: differential effects on human T and NK cells

Chang-You Wu, Massimo Gadina, Kening Wang, John O'Shea, Robert A. Seder

Journal:

European Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 234 KB

english, 2000

10

A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: Description of two unrelated cases from Brazil

Adriana A. Jesus, Mazen Osman, Clovis A. Silva, Peter W. Kim, Tuyet-Hang Pham, Massimo Gadina, Barbara Yang, Débora R. Bertola, Magda Carneiro-Sampaio, Polly J. Ferguson, Blair R. Renshaw, Ken Schoole

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 393 KB

english, 2011

11

Diffferential sensitivity of in vivo TNF and IL-6 production to modulation by anti-inflammatory drugs in mice

Marina Sironi, Massimo Gadina, Marcela Kankova, Franca Riganti, Alberto Mantovani, Mario Zandalasini, Pietro Ghezzi

Journal:

International Journal of Immunopharmacology

Year:

1992

Language:

english

File:

PDF, 409 KB

english, 1992

12

Preclinical evaluation of the ribosome-inactivating proteins PAP-1, PAP-S and RTA in mice

Fabio Benigni, Silvana Canevari, Massimo Gadina, Elena Adobati, Andrés JoséMaria Ferreri, Elena Ferraris Di Celle, Roberto Comolli, Maria Ines Colnaghi

Journal:

International Journal of Immunopharmacology

Year:

1995

Language:

english

File:

PDF, 839 KB

english, 1995

13

Not just another meeting: the coming of age of JAKs and STATs

Elbert H Chen, Massimo Gadina, Jérôme Galon, Min Chen, John J O'Shea

Journal:

Immunology Today

Year:

1998

Language:

english

File:

PDF, 160 KB

english, 1998

14

Signaling by Type I and II cytokine receptors: ten years after

Massimo Gadina, Douglas Hilton, James A Johnston, Akio Morinobu, Arash Lighvani, Yong-Jie Zhou, Roberta Visconti, John J O'Shea

Journal:

Current Opinion in Immunology

Year:

2001

Language:

english

File:

PDF, 412 KB

english, 2001

15

A critical comparison of three internalization assays applied to the evaluation of a given mAb as a toxin-carrier candidate

P. Casalini, M. Caldera, S. Canevari, S. Ménard, D. Mezzanzanica, E. Tosi, M. Gadina, M. I. Colnaghi

Journal:

Cancer Immunology, Immunotherapy

Year:

1993

Language:

english

File:

PDF, 678 KB

english, 1993

16

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

Parravicini, Valentino, Gadina, Massimo, Kovarova, Martina, Odom, Sandra, Gonzalez-Espinosa, Claudia, Furumoto, Yasuko, Saitoh, Shinichiroh, Samelson, Lawrence E., O'Shea, John J., Rivera, Juan

Journal:

Nature Immunology

Year:

2002

Language:

english

File:

PDF, 643 KB

english, 2002

17

Immune modulation: Turncoat regulatory T cells

Gadina, Massimo, O'Shea, John J

Journal:

Nature Medicine

Year:

2009

Language:

english

File:

PDF, 100 KB

english, 2009

18

Unexpected and variable phenotypes in a family with JAK3 deficiency

Frucht, D M, Gadina, M, Jagadeesh, G J, Aksentijevich, I, Takada, K, Bleesing, J J H, Nelson, J, Muul, L M, Perham, G, Morgan, G

Journal:

Genes and Immunity

Year:

2001

Language:

english

File:

PDF, 711 KB

english, 2001

19

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

Weaver, Zoë, Montagna, Cristina, Xu, Xiaoling, Howard, Tamara, Gadina, Massimo, Brodie, Steven G, Deng, Chu-Xia, Ried, Thomas

Journal:

Year:

2002

Language:

english

File:

PDF, 482 KB

english, 2002

20

Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges

Koen Vandenbroeck, Iraide Alloza, Massimo Gadina, Patrick Matthys

Journal:

Journal of Pharmacy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 625 KB

english, 2004

21

IL-33: A Sheep in Wolf's Clothing?

Gadina, M., Jefferies, C. A.

Journal:

Year:

2007

Language:

english

File:

PDF, 235 KB

english, 2007

22

Common Variants of the Class I Major Histocompatibility Complex, IL10, CPLX1, and IL23R Genes Predispose to Behçet's Disease in the Turkish Population

Barbara Yang, Elaine Remmers, Fulya Cosan, Yohei Kirino, Michael Ombrello, John O'Shea, Massimo Gadina, Daniel Kastner, Ahmet Gul

Journal:

Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

23

Cytokine Signaling: Birth of a Pathway

O'Shea, J. J., Gadina, M., Kanno, Y.

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 953 KB

english, 2011

24

ROLE OF CYTOKINES IN CANCER CACHEXIA IN A MURINE MODEL OF INTRACEREBRAL INJECTION OF HUMAN TUMOURS

Donatella R.M. Negri, Delia Mezzanzanica, Silvano Sacco, Massimo Gadina, Fabio Benigni, Laura Cajola, Gaetano Finocchiaro, Pietro Ghezzi, Silvana Canevari

Journal:

Year:

2001

Language:

english

File:

PDF, 545 KB

english, 2001

25

Advances in cytokine signaling: the role of Jaks and STATs

E Chen, M Gadina, M Chen, J.J O’Shea

Journal:

Transplantation Proceedings

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

26

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

Michael F McDermott, Ivona Aksentijevich, Jérôme Galon, Elizabeth M McDermott, B.William Ogunkolade, Michael Centola, Elizabeth Mansfield, Massimo Gadina, Leena Karenko, Tom Pettersson, John McCarthy,

Journal:

Year:

1999

Language:

english

File:

PDF, 575 KB

english, 1999

27

Cytokine Signaling in 2002: New Surprises in the Jak/Stat Pathway

John J O'Shea, Massimo Gadina, Robert D Schreiber

Journal:

Year:

2002

Language:

english

File:

PDF, 218 KB

english, 2002

28

Lack of Evidence for Activation of the Inflammasome in Typical Physical Urticarias

Komarow, H.D., Yang, B., Nelson, C., Young, M., O'Brien, M., Medic, N., Chew, S., Milner, J., Gadina, M., Metcalfe, D.D.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2011

Language:

english

File:

PDF, 41 KB

english, 2011

29

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Ghoreschi, K., Jesson, M. I., Li, X., Lee, J. L., Ghosh, S., Alsup, J. W., Warner, J. D., Tanaka, M., Steward-Tharp, S. M., Gadina, M., Thomas, C. J., Minnerly, J. C., Storer, C. E., LaBranche, T. P.,

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 2.15 MB

english, 2011

30

Janus Kinases: An Ideal Target for the Treatment of Autoimmune Diseases

Gadina, Massimo

Journal:

JID Symposium Proceedings

Year:

2013

Language:

english

File:

PDF, 230 KB

english, 2013

31

IRELAND.

Crippa, F., Buraggi, G.L., Di Re, E., Gasparini, M., Seregni, E., Canevari, S., Gadina, M., Presti, M., Marini, A., Seccamani, E.

Journal:

Year:

1908

Language:

english

File:

PDF, 403 KB

english, 1908

32

Radioimmunoscintigraphy of ovarian cancer with the MOv18 monoclonal antibody

Crippa, F., Buraggi, G.L., Di Re, E., Gasparini, M., Seregni, E., Canevari, S., Gadina, M., Presti, M., Marini, A., Seccamani, E.

Journal:

European Journal of Cancer and Clinical Oncology

Year:

1991

Language:

english

File:

PDF, 1.06 MB

english, 1991

33

Preclinical pharmacokinetics and localization studies of the radioiodinated anti-ovarian carcinoma MAb MOv18

Gadina, Massimo, Canevari, Silvana, Ripamonti, Marina, Mariani, Massimo, Colnaghi, Maria Ines

Journal:

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

Year:

1991

Language:

english

File:

PDF, 679 KB

english, 1991

34

Inhibition of TH1 immune response by glucocorticoids: Dexamethasone inhibits IL-12-induced stat4 phosphorylation in T lymphocytes

Franchimont, Denis Paul, Galon, Jerome, Gadina, Massimo, Visconti, Roberta, Chrousos, George P., O'Shea, John J.

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 353 KB

english, 2000

35

A173: Cerebrospinal Fluid Cytokines Correlate With Innate Immune Cells in Neonatal Onset Multisystem Inflammatory Disease (NOMID) Patients in Clinical Remission Treated With Anakinra

Rodriguez-Smith, Jackeline, Lin, Yenchih, Kim, Hanna, Montealegre Sanchez, Gina A., Chapelle, Dawn C., Plass, Nicole, Tsai, Wanxia, Huang, Yan, Gadina, Massimo, Bielekova, Bibiana, Goldbach-Mansky, Ra

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 37 KB

english, 2014

36

The Arrival of JAK Inhibitors: Advancing the Treatment of Immune and Hematologic Disorders

Yasuko Furumoto,Massimo Gadina

Journal:

Year:

2013

Language:

english

File:

PDF, 381 KB

english, 2013

37

Jakpot! New small molecules in autoimmune and inflammatory diseases

Ghoreschi, Kamran, Gadina, Massimo

Journal:

Experimental Dermatology

Year:

2014

Language:

english

File:

PDF, 317 KB

english, 2014

38

Super-enhancers delineate disease-associated regulatory nodes in T cells

Vahedi, Golnaz, Kanno, Yuka, Furumoto, Yasuko, Jiang, Kan, Parker, Stephen C. J., Erdos, Michael R., Davis, Sean R., Roychoudhuri, Rahul, Restifo, Nicholas P., Gadina, Massimo, Tang, Zhonghui, Ruan, Y

Journal:

Year:

2015

Language:

english

File:

PDF, 3.79 MB

english, 2015

39

CXCL12 Signaling Is Independent of Jak2 and Jak3

Moriguchi, M., Hissong, B. D., Gadina, M., Yamaoka, K., Tiffany, H. L., Murphy, P. M., Candotti, F., O'Shea, J. J.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 668 KB

english, 2005

40

Viral FLIP Impairs Survival of Activated T Cells and Generation of CD8+ T Cell Memory

Wu, Z., Roberts, M., Porter, M., Walker, F., Wherry, E. J., Kelly, J., Gadina, M., Silva, E. M., DosReis, G. A., Lopes, M. F., O'Shea, J., Leonard, W. J., Ahmed, R., Siegel, R. M.

Journal:

The Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 494 KB

english, 2004

41

Gi-Protein-Dependent Inhibition of IL-12 Production Is Mediated by Activation of the Phosphatidylinositol 3-Kinase-Protein 3 Kinase B/Akt Pathway and JNK

la Sala, A., Gadina, M., Kelsall, B. L.

Journal:

The Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 518 KB

english, 2005

42

Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-Induced Stat4 Phosphorylation in T Lymphocytes

Franchimont, D., Galon, J., Gadina, M., Visconti, R., Zhou, Y.- J., Aringer, M., Frucht, D. M., Chrousos, G. P., O'Shea, J. J.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 921 KB

english, 2000

43

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J., Johnston, J. A.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.00 MB

english, 2009

44

Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

Fukao, T., Frucht, D. M., Yap, G., Gadina, M., O'Shea, J. J., Koyasu, S.

Journal:

The Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 2.21 MB

english, 2001

45

IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma -responsive promoters in macrophages

Contursi, C., Wang, I-M., Gabriele, L., Gadina, M., O'Shea, J., Morse, H. C., Ozato, K.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 329 KB

english, 2000

46

Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity

Carroll, H. P., Paunovic, V., Gadina, M.

Journal:

Year:

2008

Language:

english

File:

PDF, 513 KB

english, 2008

47

T-bet is rapidly induced by interferon- in lymphoid and myeloid cells

Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E., O'Shea, J. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 269 KB

english, 2001

48

Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase

Elliott, J., Lynch, O. T., Suessmuth, Y., Qian, P., Boyd, C. R., Burrows, J. F., Buick, R., Stevenson, N. J., Touzelet, O., Gadina, M., Power, U. F., Johnston, J. A.

Journal:

Journal of Virology

Year:

2007

Language:

english

File:

PDF, 657 KB

english, 2007

49

Cytohesin Binder and Regulator Augments T Cell Receptor-induced Nuclear Factor of Activated T Cells{middle dot}AP-1 Activation through Regulation of the JNK Pathway

Chen, Q., Coffey, A., Bourgoin, S. G., Gadina, M.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 971 KB

english, 2006

50

STAT4 serine phosphorylation is critical for IL-12-induced IFN- production but not for cell proliferation

Morinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A., Montagna, C., Feldman, G. M., Nishikomori, R., O'Shea, J. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 245 KB

english, 2002

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